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Maternal separation with early weaning: a novel mouse model

Maternal separation is a commonly used model of early life neglect but has led to inconsistent results in the mouse. Results: In an effort to develop a mouse model of early life neglect with longlasting behavioral effects in C57BL/6 mice we designed a new maternal separation paradigm that we call Maternal Separation with Early Weaning MSEW .

Early maternal separation accelerates the progression of

Eight Balb/C mice in late pregnancy were used used for this study which later gave birth to 22 newborn pubs. Eleven additional Balb/C mice were also used as donors of uterine tissues. The 22 newborn pubs were randomly divided into 2 equalsized groups maternal separation MS and no separation NS .

Birth delivery mode alters perinatal cell death in the mouse

Csectionborn pups also emitted calls of lower amplitude i.e. softer calls in a maternal separation test. Chiesa et al. reported no effect of birth mode on USVs of mice but did not measure call amplitude. Interestingly call amplitude may be the most salient call feature inducing maternal responses in mice .

Maternal separation with early weaning: a novel mouse model

Maternal separation is a commonly used model of early life neglect but has led to inconsistent results in the mouse. Results. In an effort to develop a mouse model of early life neglect with longlasting behavioral effects in C57BL/6 mice we designed a new maternal separation paradigm that we call Maternal Separation with Early Weaning MSEW .

Early Life Maternal Separation and Maternal Behaviour

Early separation of preterm infants from their mothers has adverse longterm neurodevelopmental consequences. We investigated the effects of daily maternal separation MS of rat pups from

Maternal separation affects expression of stress response

We evaluated weight gain throughout the experiments Figure 2 to determine if the stress of maternal separation and the consumption of ethanol or sucrose affected pups weight gain. During T1 pups from the group MS presented smaller weight gain 5.295 0.610 g compared with the pups from group C 6.111 0.780 g F 669 10.58 p

Acute maternal separation potentiates the gene expression and

To examine the influence of maternal separation on the inflammatory response in PN89 mice we injected pups with LPS ip and examined inflammationinduced gene expression in the hypothalamus and liver. The average body weight of the pups was 3.8 g and variations after injection were within 1.

The impact of maternal separation on adult mouse behaviour

The maternal separation paradigm has been applied to C57BL/6J mice as an animal developmental model for understanding structural deficits leading to abnormal behaviour. A maternal separation MS model was used on postnatal day PND 9 where the pups were removed from their mother for 24 h MS24 .

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